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Mestinon contains pyridostigmine bromide and is used to treat myasthenia gravis.
To treat intestinal atony and atonic constipation take orally 60 mg every 4 hours, to treat acute myasthenia gravis use 60-180 mg of the medication 2-4 times a day.
Do not take Mestinon if you have been treated by depolarizing muscle relaxants, have hypersensitivity to Mestinon, suffer with iritis, asthma, obstructive ileus, a spasm of gastrointestinal tract, spasm of biliary or urinary tract, myotonia, Parkinson's disease, thyrotoxicosis, post-operative shock, in pregnant women.
More serious adverse reactions are severe nausea, vomiting or diarrhea, extreme muscle weakness, problems with vision, muscle cramps or twitching, drop in blood pressure, excessive salivation, frequent urination, drop in blood pressure, bradycardia, miosis, convulsions, muscle twitching, myasthenia gravis.
Mestinon used together with the depolarizing muscle relaxants, barbiturates and morphine derivatives increases their effects.
M-cholinoblockers, ganglioplegic drugs, quinidine, procainamide, local anesthetics, tricyclic antidepressants, antiepileptic drugs, and drugs for Parkinson's disease decrease effects of Mestinon.
Signs of overdose are nausea, vomiting, extreme muscle weakness, diarrhea, sweating, and muscle cramps, or weakness, involuntary defecation and urination, intestinal colic.